Forex caicedonia: Nvp Forex

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Valor presente neto

Corrija estos errores:

Interpretación:

Recuerde que aunque un proyecto ofrece un VAN positivo, los flujos de efectivo proyectados siguen siendo estimaciones. La exactitud de estas cifras proyectadas depende de la habilidad y experiencia del analista y la probabilidad de que estos flujos de efectivo se materialicen depende del riesgo financiero asociado con el tipo de proyecto que se está llevando a cabo.

Sin embargo, a pesar de que su proyecto de capital proyectado devolvió un VAN negativo, todavía puede valer la pena perseguirlo. La valoración de opciones reales en una decisión de presupuesto de capital podría aumentar el VAN de un proyecto. Por ejemplo, los proyectos de investigación y desarrollo son riesgosos porque no se garantiza el éxito del producto creado; Sin embargo, si tiene éxito, la recompensa potencial podría ser sustancial. Alternativamente, el VNA podría ser negativo también porque la tasa de retorno requerida puede ser poco realista o los flujos de efectivo proyectados pueden ser demasiado conservadores.

OOPS.

El resultado es demasiado pequeño.

Encontrar su asesor perfecto es tan simple como ir de compras para un coche. Siga leyendo para obtener más información.

Probablemente le han dicho que busque la mejor tarifa, pero ¿qué significa exactamente eso? Averigüe cómo asegurarse de que obtiene la mejor tarifa posible en su hipoteca.

Antes de intentar sacar provecho de sus teorías, debe aprender sobre los propios creadores.

Los inversionistas que toman medidas ahora pueden protegerse de los desafíos venideros que empujan a los jubilados.

preguntas frecuentes

Descubra la trayectoria profesional de CIO o CFO a CEO y cómo los roles de liderazgo organizacional tradicionales evolucionan como negocios.

Entienda las diferencias entre un Analista Financiero Colegiado y un Planificador Financiero Certificado. Aprenda cómo se acerca cada uno.

Entender qué tipos de acciones en nombre de un asesor financiero constituyen un impuesto al valor agregado (IVA). Aprenda cómo evitar.

Entender cómo los asesores financieros normalmente ejecutan las operaciones de un inversionista. Conozca los diferentes tipos de mercados e intercambios.

Tengo un poco de hilo en T2W (50.000 + vistas y 2.000 + puestos) y pensé que todos pueden estar interesados en este sencillo sistema gratuito

Voy a cargar los enlaces en los próximos posts

Mientras tanto heres mi filosofía en el G8. Disculpas por la incorrección política a continuación - He tratado de animar lo que es un bonito & # 8220; seco & # 8221; enviar.

Conocer a la familia

Sterling (Red) Volátil poco varmit, principalmente odia & # 82221; (Es decir, correlación negativa) el Yen y USD $ No amigos absolutos (es decir, correlación positiva) con cualquier otra cosa (en mi humilde opinión) quizás es más amigable y funciona con las monedas europeas que cualquier otra cosa & # 8211; Pero mucho más volátil para no ser mordido. No Forex-sabio cualquier relación que tiene es probablemente debido a su correlación negativa con el USD $ y el Yen & # 8211; Por lo que se refieren a continuación a esos comentarios

Euro (Azul) Volatilidad más baja que la mayoría de nuevo, diría, principalmente odia y # 8221; (Es decir, correlación negativa) el yen y USD $. Su mejor amigo (es decir, Correlación positiva) es el Swissie y van más lugares juntos en mi opinión. No Forex-wise cualquier relación que probablemente se relacionan más con su correlación negativa con el USD $ y el Yen & # 8211; Por lo que se refieren a los

Swissfranc (Grey) Todo lo dicho arriba en los comentarios de Euro Swissie (en mi opinión) demuestra los niveles de volatilidad más bajos de todos los principales la mayoría del tiempo útil para negociar contra las monedas de mayor volatilidad

AUS $ (Oro) Gday mate & # 8230; & # 8230 ;. No puede soportar el USD y el Yen, y debería estar de fiesta mucho con sus vecinos (NZ $) pero aparentemente no es suficiente como lo haría de manera confiable en & # 8230 ; Le encanta divertirse duro con altas tasas de interés en oferta en comparación con las otras Majors. No Forex & # 8230; & # 8230; & # 8230;; amores & # 8222; Oro (correlaciones positivas) pero suficiente para negociar con fiabilidad en (?)

NZ $ (Lightblue) Las mismas relaciones que su vecino arriba ... también es aficionado a las altas tasas de interés & # 8230; & # 8230 ;.

YEN (Amarillo) Volátil y principalmente odia & # 8222; Todas las monedas (es decir, correlaciones negativas) excepto el USD $, que generalmente se mueve en la misma dirección (pero US $ es generalmente menos volátil). La gente lo vende en tiempos percibidos de mayor riesgo / oportunidad, ya que tiene las tasas de interés más bajas por ahí. Entonces pueden comprar altos rendimientos (AUS $ y NZ $) No Forex-wise Odian & # 8222; (Correlación negativa) la mayoría de índices bursátiles y materias primas. Los comerciantes venden el Yen (el carry trade) para comprar estos (y viceversa), y lo observan contra los índices bursátiles estadounidenses para las correlaciones más cercanas (negativas)

CAD $ (Brown) Difícil de fijar este abajo - excepto movimientos generalmente negativos a US $ y Yen No Forex-wise & # 8230; & # 8230; & # 8230; Crudeoil (correlación positiva), pero suficiente para comerciar con fiabilidad en (?)

USD $ (Verde) El & # 8220; Papá & # 8221; Si el resto de la familia de forex indisciplinado le gusta o no.

Hates & # 8221; Todas las monedas (es decir, correlaciones negativas) excepto el yen. Que generalmente se mueve en la misma dirección (pero el dólar es generalmente menos volátil). La gente lo vende en tiempos percibidos de mayor riesgo / oportunidad (es la principal moneda de reserva de tenencia para la mayoría de los países) Los comerciantes contrarios lo comprarán como un refugio seguro cuando están descargando todo lo demás y los apetitos de riesgo están cayendo & # 8230; & # 8230 ; Comúnmente el dumping de los altos rendimientos (AUS $ y NZ $)

No es una divisa que odia a & # 8221; (Correlación negativa) la mayoría de índices bursátiles y materias primas. Míralo contra Gold especialmente para algunos grandes juegos de correlación (negativos).

Última edición por NVP; 04-05-2010, 09:48.

Más enlaces abajo. Ahorrarse $ 2.000

Poner los ajustes en 20ma Delta 1

Ejecutar 2 cartas junto a la otra 1min y 5min

Y el comercio de las señales cuando una moneda está por encima (o por debajo) en el mismo lado en cada marco de tiempo

Encontrar una moneda haciendo lo opuesto al comercio que el emparejamiento

Para USD X oficios (que claramente es mejor scalping debido a los spreads) cuando usd es similarmente por encima o por debajo de ambos gráficos que prefiero ver el Yen haciendo lo mismo que USD para confirmación.

Usted también puede cuero cabelludo el U / J utilizando esta metodología, pero ver hilo para más detalles

El comercio de cualquier otro G6 si se encuentra en la posición opuesta a la Yen / USD. Con respecto a la especialización más contacto conmigo en el hilo, ya que tengo muchos indicadores híbridos muchos corriendo y pronto disponible

Respecto a Neil NVP

NASDAQ OMX Nordic

NASDAQ OMX Nordic es el conglomerado de 4 intercambios nórdicos - Copenhague, Helsinki, Islandia & amp; Estocolmo.

Las acciones que figuran en OMX Nordic son principalmente danesas, suecas, islandesas o finlandesas.

Los intercambios nórdicos pueden remontarse a sus raíces hace casi 400 años con la fundación de la Bolsa de Valores de Copenhague. El antiguo edificio de la bolsa de valores, construido por el rey Christian IV en 1625, todavía se encuentra en el centro de la capital danesa. La leyenda lo tiene el buidling es protegido por su espiral de la cola de dragón, significando que ha escapado fuego y daño incluso mientras que edificios vecinos han sido destruidos.

Horario de operaciones nórdicas de NASDAQ OMX

Las horas de negociación para el NASDAQ OMX Nordic dependen de los mercados que lo componen.

Copenhague - 8am hasta 4pm GMT

Helsinki - 8am hasta 4:30 pm GMT

Islandia - 10:30 am hasta 4:30 pm GMT

Estocolmo - 8 am hasta 4:30 pm GMT

¿Cuál es la diferencia entre el valor presente neto y la tasa interna de rendimiento? ¿Cómo se usan?

Ambas mediciones se usan principalmente en el presupuesto de capital. El proceso por el cual las compañías determinan si una nueva inversión o oportunidad de expansión vale la pena. Dada una oportunidad de inversión, una empresa necesita decidir si emprender la inversión generará ganancias o pérdidas económicas netas para la compañía.

Para ello, la empresa calcula los flujos de efectivo futuros del proyecto y los descuentra en valores de valor presente utilizando una tasa de descuento que representa el costo del capital del proyecto y su riesgo. A continuación, todos los flujos de efectivo positivos futuros de la inversión se reducen a un número de valor actual. Restar este número del desembolso de efectivo inicial requerido para la inversión proporciona el valor actual neto (VAN) de la inversión.

Vamos a ilustrar con un ejemplo: supongamos que JKL Media Company quiere comprar una pequeña editorial. JKL determina que los flujos de efectivo futuros generados por el editor, cuando se descontan a una tasa anual del 12%, arrojan un valor actual de $ 23.5 millones. Si el dueño de la compañía editorial está dispuesto a vender por $ 20 millones, entonces el NPV del proyecto sería $ 3.5 millones ($ 23.5 - $ 20 = $ 3.5). El VAN de $ 3.5 millones de dólares representa el valor intrínseco que se agregará a JKL Media si realiza esta adquisición.

Por lo tanto, el proyecto de JKL Media tiene un NPV positivo, pero desde una perspectiva de negocio, la firma también debe saber qué tasa de rendimiento será generado por esta inversión. Para ello, la empresa simplemente recalcularía la ecuación NPV, esta vez estableciendo el factor NPV a cero y resolviendo la tasa de descuento ahora desconocida. La tasa que produce la solución es la tasa interna de retorno del proyecto (IRR).

Para este ejemplo, la TIR del proyecto podría ser, en función del momento y proporciones de las distribuciones de flujo de efectivo, igual al 17,15%. Por lo tanto, JKL Media, dado sus flujos de efectivo proyectados, tiene un proyecto con una rentabilidad del 17,15%. Si hubiera un proyecto que JKL podría emprender con una TIR más alta, probablemente seguiría el proyecto de mayor rendimiento en su lugar. Por lo tanto, puede ver que la utilidad de la medición de la TIR radica en su capacidad para representar el retorno de cualquier oportunidad de inversión y compararla con otras posibles inversiones.

Para obtener más información, lea Hacer el inventario de los flujos de efectivo descontados. Cualquier cosa pero ordinaria: calcular el valor presente y futuro de las anualidades y los inversores necesitan un buen WACC.

Aprenda sobre la regla del presupuesto 50/30/20 de Elizabeth Warren, un plan simple y eficaz para la administración del dinero personal y la riqueza. Leer respuesta >>

La fórmula para calcular el capital de trabajo es sencilla, pero proporciona una gran visión de la salud a corto plazo de un. Leer respuesta >>

Aprenda por qué los cambios en el capital de trabajo neto (VPN) deben incluirse en los cálculos del valor actual neto para analizar los proyectos. Leer respuesta >>

Comprender las diferencias entre capital de trabajo y capital fijo, incluyendo definiciones y ejemplos de cómo las empresas. Leer respuesta >>

Aprenda sobre los tres factores principales que determinan cuánto capital de trabajo es necesario para una pequeña empresa, incluyendo negocios. Leer respuesta >>

Aprenda sobre el capital de trabajo neto y qué una figura alta indica sobre las perspectivas financieras de una compañía, incluyendo la importancia. Leer respuesta >>

NeuroVive Pharmaceutical (NVP) Cotización en tiempo real

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Búsqueda de símbolos

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Las mejores historias de MarketWatch

Archivo de la categoría: Owen Li

CNBC tiene la historia de Owen Li, el fundador de Canarsie Capital en Nueva York. El martes, dijo que el fondo de cobertura había perdido casi 200.000 dólares de la capital de la firma - desde los aproximadamente 100 millones de dólares que tenía a fines de marzo.

Una pérdida de 99.8% en 9 meses.

Asumo la responsabilidad por este terrible resultado, & # 8221; Li escribió en una carta a los inversores, que fue obtenido por CNBC. com.

Mi única esperanza es que usted entienda que actué en un intento - aunque equivocado - de generar retornos más altos para el fondo y sus inversionistas. Pero aun así, actué excesivamente, causándole pérdidas devastadoras para las que no hay excusa, & # 8217; Añadió.

Li es un antiguo comerciante del Grupo Galleon de Raj Rajaratnam, que se desplomó en medio de los cargos de información privilegiada.

Parece que no podría hacerlo tan bien sin la información interior de Raj. Si usted consigue la ocasión en el reloj del fin de semana el informe de primera línea en la información privilegiada en Galleon. It & # 8217; s en Netflix.

Mientras tanto, no fue un gran año para los titanes del fondo de cobertura, a pesar del aumento del 10% en el S & amp; P 500. David Tepper, que fue el administrador de fondos mejor pagado en el mundo en 2017, ganando una friolera de $ 3.5 Mil millones. Reveló que su fondo sólo subió un 2,2% en 2017.

Valor Actual Neto - VAN

¿Qué es el valor actual neto?

La técnica de valoración, conocida como valor presente neto o VAN. Permite a una empresa proyectar la rentabilidad potencial de los proyectos descontando las expectativas de flujo de efectivo futuro y comparando la suma de estos flujos de efectivo con el gasto de capital inicial requerido para financiar el proyecto.

Los flujos de efectivo futuros deben ser descontados para realizar una comparación entre manzanas y manzanas. Por ejemplo, $ 100 hoy no es lo mismo que $ 100 en 3 años. $ 100 hoy tendrán la oportunidad de ganar interés compuesto sin riesgo durante 3 años y por lo tanto tendrán un valor que es más alto que $ 100 al final de 3 años. Es por ello que debemos descontar o eliminar el componente de intereses del flujo de caja futuro, lo que nos permite poner la inversión de capital inicial y los flujos de efectivo futuros en condiciones de igualdad.

Fórmula NPV

A continuación, verá la fórmula para calcular el valor presente neto. Básicamente, estamos descontando cada flujo de caja futuro por un factor de descuento para llegar al valor actual de cada flujo de efectivo. La fórmula resume cada uno de estos valores y resta la inversión inicial en el proyecto. Un VAN mayor que 0 indica que el proyecto agregará valor a la empresa, mientras que un VAN de menos de 0 indica que la empresa se verá afectada negativamente por el proyecto; Sin embargo, puede ser necesario continuar con el proyecto con el propósito de controlar los daños o de prevenir más pérdidas.

Hay una zona gris donde el NPV está cerca de 0 o 0. En este caso, la administración tendrá que decidir si hay beneficios intangibles como el aumento de la conciencia de la marca o el liderazgo en la comercialización de un producto que influirá positivamente en la empresa la carretera.

Desventajas del valor actual neto

La fórmula que se muestra arriba parece bastante directa, y lo es. No explica muchos de los riesgos del mundo real implicados con emprender un nuevo proyecto. El riesgo de gestión, los flujos de efectivo desiguales, los impuestos y otras opciones de inversión crean incertidumbre que este cálculo no tiene en cuenta. Por ejemplo, una empresa puede encontrarse en una posición de generar flujos de efectivo desiguales debido a los costos diferentes en las diferentes etapas de un proyecto.

Si bien no debe descartarse en todos los casos, el aumento de la tasa de descuento para compensar el riesgo adicional puede plantear problemas si un proyecto tiene flujos de efectivo negativos en algún momento. Una tasa de descuento más alta disminuirá el verdadero impacto de la pérdida. Un impacto secundario del aumento de la tasa de descuento para tener en cuenta el riesgo radica en la composición de esta prima de riesgo en el tiempo. Comenzará a aumentar exponencialmente la tarifa de descuento y drásticamente reduce el VAN que puede no ser muy exacto.

NVP Exhibits amplía su gama de espacios para exposiciones adaptables para suelos comerciales

NVP Exhibits ha creado una gama de alta flexibilidad, altamente escalable exhibición de exposición de suelo exposición comercial que puede ayudar a las empresas a hacer el mayor impacto en las ferias.

San Francisco, CA. Estados Unidos de América - - 8 de abril de 2017 / MarketersMedia / - Las ferias comerciales son una forma increíble para los fabricantes y los vendedores de negocios a distinguirse, hacer conexiones y mostrar nuevos productos asombrosos. Casi toda la tecnología se estrena en las ferias comerciales y, como tal, la competencia es en todos los tiempos altos para destacar y hacer un impacto. En Australia, NVP Exhibits ofrece una alternativa al stand de exposición alquilado, ofreciendo a las empresas expositores flexibles y escalables que se destacan de la multitud y funcionan como ningún otro.

Los stands incluyen tres por tres metros y tres por seis metros áreas y puede incluir torres, accesorios y más para adaptarse a cualquier tamaño de área de exposición empresas han reservado para sus ferias. Éstos usan el sistema de la pared, una cabina híbrida o los espacios flexibles que pueden crear una sala de estar o una recepción virtual dependiendo de cuál servirá mejor cómo los delegados interactúan con el producto.

La compañía también se destaca en la fabricación de soportes personalizados portátiles para empresas especializadas que tienen una visión clara de cómo quieren presentar su producto, y se especializan en hacer esas visiones ambiciosas una realidad funcional. Su sitio web no tiene escasez de grandes ejemplos para obtener los jugos creativos que fluye.

Un portavoz de NVP Exhibits explicó: "Muchas empresas asisten a un gran número de ferias en Australia cada año y, sin embargo, alquilan stands de exposición cada vez que lo hacen, lo que les cuesta mucho más que una inversión en largo plazo, stands de alta calidad portátil. NVP Exhibits se enorgullecen de crear los mejores soportes posibles que son capaces de ser rediseñados y reordenados de manera flexible en el lugar para que coincida con el espacio que se pone pulg Como tal, proporcionan una solución perfecta para las empresas que quieren ahorrar dinero mientras sigue haciendo El mayor impacto, con expositores que están literalmente pendientes en su campo. Estamos actualizando constantemente nuestras opciones disponibles y 2017 ha visto nuevas configuraciones innovadoras disponibles. "

Acerca de NVP Exhibits: NVP Exhibits es un negocio basado en Sydney que ofrece expositores y exhibiciones de ferias comerciales a toda Australia. Sus stands de exposición son perfectos para expositores en curso, ofreciendo bajos costos de operación, un alto nivel de adaptabilidad para coincidir con diferentes espacios, y no requieren herramientas para la instalación. Los stands también se pueden alquilar para un uso a corto plazo, y proporcionan fácil almacenamiento y transporte de gráficos de alto impacto que requieren atención.

Para obtener más información acerca de nosotros, visite http://www. nvp. com. au/

Información de Contacto: Nombre: Joe Bragg Organización: Brandoutreach Teléfono: (415) 632 1664

ID de la versión: 39658

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La forma más segura de jugar los mercados de divisas

Sterling tanked ayer, cayendo a su nivel más bajo en casi un año frente al dólar. ¿Por qué?

Tal vez sea mejor preguntar: ¿por qué no? & # 8221; Hay muchas razones para odiar la libra. El más grande es el riesgo político. Con el reciente lote de encuestas de opinión que demuestran que el Partido Laborista podría incluso ganar las próximas elecciones, los inversionistas ya no se sienten seguros de que saben quién dirigirá el país en menos de cuatro meses.

Luego hubo datos de préstamos del Banco de Inglaterra. El número de préstamos hipotecarios aprobados para la compra de una nueva casa se desplomó un 17% mensual en enero, cayendo a cerca de 48.000. Y además, la decisión de la aseguradora Prudential de comprar negocios asiáticos del grupo estadounidense AIG también tuvo un impacto. El acuerdo de 35.000 millones de dólares significa que tendrá que vender un montón de libras esterlinas.

Así que hay muchas razones para odiar la libra. Ponerse en la cola para vender parece un no-brainer. Hay sólo un problema - la mayoría de las otras principales monedas tienen casi exactamente los mismos problemas ...

Usted debe pensar dos veces antes de comenzar a operar con divisas

Una cosa resume todo lo que necesitas saber sobre la caída de la libra esterlina ayer, dice David Wighton en The Times & # 8211; La libra incluso disminuyó frente al dólar zimbabuense. Eso es bastante condenatorio. & # 8220; Gordon Brown ha sido acusado de muchas cosas. Pero la perspectiva de su reelección resultando en que la moneda de Robert Mugabe sea preferida a la libra esterlina debe ser seguramente una de las más dañinas. & # 8221; Y los analistas se alinearon para entregar nuevos objetivos para la libra ayer, que van desde alrededor de $ 1.40 a $ 1.20 y menos. ¿Así que es hora de apilar y esterlina corto?

Es ciertamente fácil de hacer. Y la perspectiva de la libra es sombría. Pero hay algunas razones por las cuales usted debe pensar dos veces antes de que usted decida comenzar a negociar monedas. El escritor estadounidense Porter Stansberry hizo algunos muy buenos puntos en su boletín DailyWealth ayer. Recientemente asistió a una reunión en la que una firma de administración de patrimonios estadounidense estaba tratando de alentar a los inversionistas privados acomodados a comenzar a especular sobre monedas, usando una estrategia de comercio. Ellos tomarían préstamos en las divisas de menor rendimiento e invertirían en el rendimiento más alto.

La estrategia ha funcionado bastante bien en el pasado. Pero, dice Stansberry, eso no significa que va a seguir funcionando. Nunca había visto una firma de Wall Street dar una presentación de moneda apalancada a clientes minoristas antes. En mi experiencia, cualesquiera que sean los grandes corredores que están lanzando a clientes minoristas, eso es lo más probable que explote a continuación. Un año de sus acciones de puntocom, un año de sus valores respaldados por hipotecas, un año de futuros de materias primas, y así sucesivamente ... & # 8221;

Todas las principales divisas del mundo están en un lío

El verdadero problema, como señala Stansberry, es que todas las principales monedas del mundo están en un lío. Y el sistema ya no está fundado en oro. De hecho, lo principal que respalda al sistema monetario global es la deuda del gobierno de Estados Unidos. Dado que el déficit de Estados Unidos es poco mejor que el de Gran Bretaña o Grecia, eso no es alentador. Como dice Stansberry: Los activos de reserva más grandes del sistema monetario del mundo son las obligaciones de una nación en bancarrota (los Estados Unidos) que debe imprimir dinero para pagar sus propios déficit anuales & # 8221;

Informe especial LIBRE de la revista de MoneyWeek: ¿Cuándo los precios de la casa abajo hacia fuera & # 8211; Y ¿cómo lo sabrás?

¿Por qué los precios inmobiliarios del Reino Unido van a caer un 50%

Cuando llegue el momento de volver a comprar la propiedad a mitad de precio

Usted puede argumentar que el comercio de divisas es un juego de suma cero. Y así, independientemente de lo horribles que son las condiciones para cada moneda de papel, si uno está cayendo, otro tiene que estar subiendo. Sin embargo, el punto es que juzgar esto va a ser cada vez más difícil. Si cada moneda es vulnerable, entonces sólo toma unas pocas palabras mal-juzgadas de un banquero central o un político (o una encuesta de opinión de miedo) para golpear una moneda fuera de su perca.

Por ejemplo, una razón por la que la libra esterlina está tomando la mayor parte de esta semana es porque los inversionistas han decidido que Alemania salvará a Grecia. Así que, por el momento, consideran que el Reino Unido se parece a Grecia, pero sin que los alemanes estén detrás de él. Pero sólo se necesita una crisis en España, o una gran grasa & # 8220; nein & # 8221; Desde Berlín, para volver a poner el euro en la línea de fuego.

& # 8220; ¿Qué pasará con estas estrategias [de comercio de divisas] mientras la volatilidad se dispara y las grandes monedas se derrumban? Nadie sabe. Pero una cosa que sé con seguridad. No terminará bien para los inversores minoristas. & # 8221;

No es para decir que usted no puede apostar por los movimientos monetarios. Creemos en el corto plazo, el dólar sigue siendo una apuesta decente para ir más alto, en particular frente al euro. Y si usted tiene una olla de dinero que usted está feliz de apostar, y puede permitirse perder, a continuación, propagación de apuestas puede ser una manera divertida de hacerlo (puede comparar los proveedores aquí, utilizando nuestro servicio de comparación de propagación de apuestas) .

Pero por la bondad & # 8217; Sake establecer una stop-loss y se adhieren a ella. Y nunca imaginar por un momento que las apuestas a las monedas está invirtiendo, independientemente de cuántas empresas lanzar & # 8216; llevar el comercio & # 8217; O euro corto & # 8217; los fondos negociados en bolsa. Este es un área del mercado que sólo va a volverse cada vez más volátil e impredecible a medida que los problemas de deuda soberana comienzan a explotar en todo el mundo.

Proteja su riqueza con oro

Si desea beneficiarse de la tendencia más significativa a largo plazo de la moneda - la pérdida de la fe en el dinero respaldado por el gobierno - entonces usted debe comprar oro. Me doy cuenta de que a algunos lectores les cuesta entender por qué continuamos con esto. Pero el oro alcanzó un máximo récord contra la libra esterlina de ayer (más de £ 740 la onza). Los compradores de oro de la zona euro también registraron precios récord en las últimas semanas. Así que en términos de proteger su riqueza, el metal amarillo está haciendo bastante bien hasta ahora.

Si y cuando los gobiernos finalmente decidan que proteger el valor del papel moneda es más importante que mantener la ilusión de crecimiento económico a corto plazo en el camino, el mercado alcista de oro habrá terminado. Lamentablemente, sospecho que todavía está lejos. El Dr. Marc Faber del informe Gloom, Boom and Doom reporta que & # 8216; real & # 8217; Los tipos de interés (es decir, ajustados por la inflación) en los Estados Unidos no se moverán a territorio positivo en ningún momento en los próximos 10 años. & # 8221; Si su papel moneda está perdiendo valor, ¿por qué no tendría oro?

Nuestro artículo recomendado para hoy

Anthony Bolton, gerente de fondos de Superstar, está de vuelta con un nuevo fondo de China. Pero sus altas tarifas & # 8211; Demasiado común en la ciudad, desafortunadamente & # 8211; Lo convierten en uno para el inversor medio de evitar, dice Merryn Somerset Webb.

¿Por qué ahora no es el momento de invertir en buy-to-let

Invertir en comprar-para-dejar ha sido tradicionalmente una manera confiable de dibujar en un rédito bastante decente. Pero en 2017 buy-to-let viene con una serie de peligros ocultos que podrían resultar un enorme drenaje de su riqueza personal. El canciller Osborne está haciendo más difícil y más difícil para los inversores hacer realmente comprar-a-dejar valer la pena.

No se preocupe, el equipo de MoneyWeek se ha sentado y ha presentado un plan de ingresos alternativo que podría resultar mucho más confiable en los próximos años.

Para reclamar su informe gratuito y empezar a recibir MoneyWeek gratuito de correo electrónico diario por la mañana. Simplemente introduzca su dirección de correo electrónico debajo.

Simon Popple Metales y Mineros

Más de MoneyWeek

Me pregunto si un fondo indexado global podría ser una manera razonable de protegerse contra un colapso de la libra esterlina. Los únicos ejemplos que he encontrado son Standard Life Global Index-Linked Bond R y Royal London Index-Linked Gilt Trust, sin embargo sólo he estado buscando OEICs puedo poner en un ISA. También sólo consiguen dos estrellas de Morningstar.

Fui mal mal en mi post anterior. Royal London Index - Linked Gilt Trust Inc no es global, así que no es el tipo de inversión que tenía en mente.

Sabemos que le gusta el oro, pero ¿qué es lo que le gusta? Significa para ti

Si alguien tiene 0% de NAV de oro, puede que decida que se trata de & # 82221; Oro e ir para el 5%. Algunos errores hardbitten de oro como # 8221; Oro y así tener el 100%. Después de todo un stock dip doble parece ser generalmente esperado también.

Cualquier persona podría ver su artículo como apoyar su punto de vista!

¿Qué hay de otra manera segura de almacenar efectivo (lugar seguro y caja de divisas segura) para aquellos que ya han leído muchos artículos de oro? ¿Por favor?

Suzy, en la sección Inversiones hay un artículo & # 8220; Bonos: la carrera hacia el fondo & # 8221; (O pruebe este enlace: http://www. moneyweek. com/investments/bonds-the-race-to-the-bottom-454p32.aspx) Los dos últimos párrafos sugieren bonos en el extranjero relativamente seguros, y un fondo que invierte en Con un rendimiento decente. Podría ser relevante.

Interesante artículo y estoy de acuerdo en que la cesta del G8 es actualmente tan popular entre los inversores como el & # 8220; Good Husbandry & # 8221; Revista en el vestidor de Chelsea & # 8230 ;.

El oro siempre vale la pena un punt contra el G8, ya que no caen en prensas de impresión en grandes cantidades en la actualidad, pero comprar como un comercio de canastas en todas las monedas para equilibrar el riesgo y esperar un buen momento para entrar en El rebote & # 8230 ;.

El comercio de divisas es un campo especializado y las volatilidades actuales están haciendo que los plazos más largos sean mucho más riesgosos a menos que se establezcan paradas a niveles absurdos y no lo hagan. No es obvio, pero si los mercados a su vez te matan & # 8230 ;.

Como arreglar su cocina de gas con una navaja y un fósforo encendido & # 8211; No hacerlo a menos que tenga la experiencia y el conocimiento!

Buena NVP comercial

Quiero decir VENTA de EuroZone contra Yen / USD ** COMPRAR

Dije que lo dejaran a los expertos, así que obviamente también lo necesito.

Lo siento & # 8211; Día ocupado y cerebro duele NVP

** ive los apodó el Tag Team, ya que tienden a moverse por todas partes juntos en el mercado Forex!

Lo siento solo vi suzy & # 8217; s comentario número 4

Sí & # 8211; Usted podría tratar de preservar su base de capital mediante el mantenimiento de una cesta de monedas ponderadas a sus niveles de fuerza relativa con los ajustes realizados periódicamente a capitalización en el aumento de las monedas y deshacerse de las monedas que caen

No exactamente tan simple como mantener el dinero bajo la cama, pero probablemente más practival en la preservación de la Nest egg!

Para el inversor a largo plazo, ¿por qué no comprar acciones defensivas?

Eliminar la especulación de la especulación monetaria.

Rendir más que efectivo en 5-6%.

Empresas sólidas que probablemente son más solventes que muchos de los países occidentales.

De lo contrario comprar el zloty. Tengo una cantidad en Polonia y se está realizando muy bien v la gran libra británica.

Todo por el oro, pero acaba de vender 3/4 de mi oro ETF & # 8211; El mercado del lingote es fraccionario como las monedas fiat y las porciones de barras falsas del tungsteno en bóvedas centrales.

También lee los T & # 8217; s de mi etf (oro respaldado físicamente en bóvedas BRITÁNICAS también) & # 8211; Mi sinopsis (aproximadamente el 90% + precisa)

Parte 1 de 2 Oro es bastante asignado, pero algunos no son. No lo aseguramos, aun así no somos responsables de CUALQUIER PÉRDIDA & # 8222; (Siempre cubrir el extra oops) o robo (nunca se sabe). El custodio es HSBC & # 8211; O sus amigos, o incluso amigos de sus amigos. Si las contrapartes no pagan, no creen, no somos responsables, es su paloma. Hemos enumerado algunos riesgos, pero no podemos molestarnos en enumerar el resto. Usted puede tener su oro, pero tenemos que cobrar y debe enviarlo a uno de nuestros amigos cuentas no asignadas; Y se puede solucionar con ellos. We intend to track the spot gold price, but then again, nobody gets it right all the time.

Part 2/2 There are probably a few more possible not responsibles, but we are not responsible for listing them all, and any we have missed, we are not responible for those either.

Rest assured somebody or other, does a sort of audit and provides a huge list of numbers on our website (mind you, no responsibility accepted for them or failure of website).

And by way of “further reassurance”, good old English Law shall apply to any dispute (but don’t bother, we have checked, you haven’t got a leg to stand on). SO FINALLY we shall round off with the familiar, nothing should be construed as “financial advice”, just to be on the safe side.

Oh & P. S – No responibility is accepted for any errors or ommisions.

Check out the “prospectus” at Gold Bullion Securites (An ETF) & I still own some – but a lot less than I did !

I agree with many of the comments above. Currency speculation is about the biggest mug’s game there is, and it’s only compounded by the inordinate amount of random government intervention we see these days. I would add to Tom F’s comments that after recent weakness, there are some solid banks that offer attractive valuations and dividend yields as well as the posibility of decent growth.

hi folks, i see yamana mining climbing steadily as predicted by moi well another nugget for you max petroleum (mxp. l) watch them both climb steadily over the next 6-9 months the former will continue and the later should take a nice little earner over the short term. watch this space and send your thank yous in the summer.

Thanks Michael. Thanks NVP. Counterparty risk troubles me a lot if the basket were eg spread betting obligations. And boy will I have trouble weighting it.

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Neurovive Pharmaceutical: Board Selects New CEO Erik Kinnman to Lead NeuroVive

NeuroVive Pharmaceutical (STO:NVP)

NeuroVive Pharmaceutical AB (publ) board of directors is pleased to announce that it has selected Erik Kinnman as NeuroVive's Chief Executive Officer (CEO). Erik Kinnman will assume the new role on the 14th March 2017, leaving Chief Medical Officer (CMO) and Chief Operating Officer (COO) roles within his own consultancy business.

Erik Kinnman is a seasoned life science executive with broad experience and understanding from the industry across a variety of businesses and functions. He has held a number of senior leadership positions in biopharmaceutical companies such as AstraZeneca and Sobi. His expertise and experience includes clinical development, business strategy, business development, and investor relations. Erik Kinnman also has experience from the financial sector. In addition, he holds an Executive MBA from the Stockholm School of Economics and has comprehensive scientific qualifications from the Karolinska Institutet, which has rendered him a Ph. D. and an Associate Professor. Moreover, Erik Kinnman is an M. D. board certified in Neurology and Pain Management.

"The NeuroVive Board and I are confident that Erik Kinnman is the right person to lead the company, its strategy, and leverage the opportunities. The combination of his strategic vision and medical expertise is an excellent fit with NeuroVive's strategy refocused towards R&D. Erik Kinnman is a strong and experienced leader who has a proven ability to translate scientific, clinical and business strategy into execution," commented Gregory Batcheller, Chairman of the NeuroVive Board of Directors. "He will provide expertise and focus across the organization and establish solid partnerships that will enhance our R&D program further. His broad experience grounded in research, medicine and the biopharmaceutical industry is exactly what we need to lead this organization forward."

"I am excited about NeuroVive, the CEO role, and the opportunity to contribute to the success and growth of the company. NeuroVive is a highly innovative organization and I am convinced that it has great potential in its range of novel treatment opportunities and their commercial potential. NeuroVive and its partners are truly led by a purpose and passion to make a difference and meaningful impact to patients affected by mitochondrial disorders. I will enable our researchers and partners to deliver on the opportunities in the clinical projects, as well as in the early pipeline to drive the value of NeuroVive." says Erik Kinnman.

Erik Kinnman succeeds interim CEO Jan Nilsson, who will resume his position as Chief Operating Officer for NeuroVive. Jan has made significant contributions to move the organization forward. The recent partnership deals with both Isomerase and the University of Pennsylvania (UPENN) have been significant achievements under Jan's leadership. Jan's extensive NeuroVive knowledge and commitment to move the organization forward have been greatly appreciated by both the teams and board of NeuroVive.

NeuroVive Pharmaceutical AB (publ) is a pioneer in mitochondrial medicine and a company committed to the discovery and development of highly targeted candidates that preserve mitochondrial integrity and function in areas of significant therapeutic need. NeuroVive's business approach is driven by value-adding partnerships with mitochondrial research institutions and commercial partners across the globe. NeuroVive's portfolio consists of two clinical projects in acute kidney injury (AKI) and traumatic brain injury (TBI) with candidates in clinical and preclinical development and two drug discovery platforms. The NeuroSTAT® product has orphan drug status in Europe and in the US for treatment of moderate to severe traumatic brain injury and is currently being evaluated in a study, CHIC. Ciclosporin is being evaluated in an on-going study, CiPRICS, in acute kidney injury during major surgery. NeuroVive's shares are listed on Nasdaq, Stockholm, Sweden.

NeuroVive Pharmaceutical AB (publ)

Medicon Village, SE-223 81 Lund, Sweden

Tel: +46 (0)46 275 62 20 (switchboard), Fax: +46 (0)46 888 83 48

NeuroVive Pharmaceutical AB (publ) is required to publish the information in this news release under The Swedish Securities Market Act. The information was submitted for publication on 23 February 2017, at 08 30 CET.

NeuroVive Pharmaceutical AB (publ) - the mitochondrial medicine company. The company is listed on NASDAQ OMX Stockholm, Small Cap, under the ticker symbol NVP. The share is also traded on the OTC market in the US. NeuroVive Pharmaceutical (OTC: NEVPF ) trades on the OTC Pink Market. Investors can find Real-Time quotes and market information for the company at www. otcmarkets. com/stock/NEVPF/quote

This information was brought to you by Cision http://news. cision. com

NeuroVive Christine Tadgell or Gregory Batcheller Tel: +46 (0)275 62 20 ir@neurovive. com

Over the years I developed many Indies & EA’s. I recently reveiewd the ones that I consistantly use and keep developing.

I went to the Forex market and installed 7 pipes – one to each major currency. I also put a meter on each pipe to monitor the pips flow amount (and direction +/-) to/from each currency from day start. More advanced versions also monitors, per currency, pips flow amount per second/Minute/Hour – like a speedometer… That’s one usefull tool, that’s telling you to what currency the pips are going to and from what currency they are getting out – absolute measurement without any relation to TF.

( Top left on EURUSD chart)

The other tool is for synthetic pair “Blind” comercio. Synthetic pair example: EURUSD/GBPUSD=EURGBP You can “Blindly” trade any other such Triangulation currency pairs. That tool displays the GBPUSD (Yellow) on top of the current EURUSD chart. How to trade “Blindly”: Whenever GBPUSD is above EURUSD and makes new HIGH while EURUSD doesn’t, it’s time to SELL EURGBP… and the opposite for BUY.

That’s without even looking at the EURGBP chart… (I just put it for demonstration in the attachement).

This method is PERFECT for small pips profit as suggested in the “Compounding & 1 Pip” thread here. G.

Attachments:

You must be logged in to view attached files.

Count the pips change for each currency pair, and add it to that CURRENCYtotal. Example: If EURUSD is UP by 5 pips than EURtotal=EURtotal+5 and USDtotal=USDtotal-5. Repeat the above for all currency pairs. To view the flow ROC (Rate of Change) – show only the total change from previous total (Adding +/- for relevant direction). You can also enhance the above by converting pips to their $value in order to see real $$$ money flow. G.

Thanks for sharing this G Sorry for asking these beginner questions below G :

*) About pips change (difference), if we trade on TF M1, do we calculate the difference in every 1 minute (ex. at open of new candle) or in every tick ?*) And how to convert pips to $value to know the money flow ?

It doesn’t matter on which TF you update, since M5 is accumulation of 5 M1. The result will be the same, rhe only difference will be the rate of data updates. Pip value depends on the currency pair and you can find that in marketinfo. That info is only for reference value in order to make all pips translate to comon denominator in the currency total.

“Whenever GBPUSD is above EURUSD and makes new HIGH while EURUSD doesn’t, it’s time to SELL EURGBP… and the opposite for BUY.”

first screen shot is GBPUSD above EURUSD (with new high only on chart)

second screen shot is EURGBP

Attachments:

You must be logged in to view attached files.

Ok, thanks. I have some indicators that do it this way also, I just thought you had a different way.

The reason I was asking is the inconsistency of ploting an overlayed chart in this way. Depending on the chart area size and position of local maximum and minimum prices of the two currencies, the relative position of these two charts can change with a single window resizing.

How do you deal with this since one of your entry rule says that ‘Whenever GBPUSD is above EURUSD…’?

Ok, thanks. I have some indicators that do it this way also, I just thought you had a different way. The reason I was asking is the inconsistency of ploting an overlayed chart in this way. Depending on the chart area size and position of local maximum and minimum prices of the two currencies, the relative position of these two charts can change with a single window resizing. How do you deal with this since one of your entry rule says that ‘Whenever GBPUSD is above EURUSD…’? Thanks Vlan

I’m not sure that I understood you, but I’m limiting the display to the last xxx bars. In my case the overlay is limited to last 300 bars.

I have no problem of displaying 4 different overlays on a single chart.

This is usually done to catch and pinpoint single currency movement.

A screenshot should do better explanation than me :)

In attached images, the green line is the EU and the yellow is the overlying GU.

Both screenshots were taken seconds apart, yet the yellow GU line is positioned very differently.

While in the first picture, the two lines cross several times today, in the second picture they don’t.

The reason for this is that I widened my chart window by few bars, (note the vertical line on the left side), causing new minimum GU price to appear and thus pushing the whole GU chart up.

This reply was modified 8 months, 2 weeks ago by VlanFx.

Attachments:

You must be logged in to view attached files.

A screenshot should do better explanation than me :) In attached images, the green line is the EU and the yellow is the overlying GU. Both screenshots were taken seconds apart, yet the yellow GU line is positioned very differently. While in the first picture, the two lines cross several times today, in the second picture they don’t. The reason for this is that I widened my chart window by few bars, (note the vertical line on the left side), causing new minimum GU price to appear and thus pushing the whole GU chart up. V.

Again, I fail to see the issue…

The “Crossing” means nothing, only the relative movement of one pair in relation to the other.

Your signal, in the EURUSD & GBPUSD overlay case, is when GBPUSD is going UP/DOWN while the EURUSD stays flat or going in the opposite direction.

The logic behind trading the overlay is to neutralize the USD and visualy “see” EUR going up and GBP going down (or vice versa) in order to trade the triangulation outcome of those pairs – which is the EURGBP. EURUSD going UP and GBPUSD going DOWN == BUY EURGBP (and vice versa).

Same goes to any other triangulation between currency pairs. The beauty of this that it’s predictive, blind trading, and never fails… It doesn’t guarranty gazilion pips, but it does guarranty a move on the resulting triangular currency pair.

Another, more complicated method is to put several overlays on the same chart, such as AUDUSD, NZDUSD, GBPUSD on top of EURUSD chart (note that USD, in this sample case, is on the right side of all pairs – making it “common denominator”).

Whenever ALL are pointing UP – Sell USD across the whole Forex market (and vice versa). That’s a STRONG sign of USD weakning.

Ok thoughts on CS type indicators inc goldmeter

1 LWMA and divided up by the number of components – malo

As above but each then divided up by its market share (US dollar taking up the greatest share)

How about basing it on % change then aggregating or % ROC.

Anyone else able to add.

Apologies if it strays off topic a bit and what I have written appears to be complete twaddle

Ok thoughts on CS type indicators inc goldmeter

1 LWMA and divided up by the number of components – bad

As above but each then divided up by its market share (US dollar taking up the greatest share)

How about basing it on % change then aggregating or % ROC.

Anyone else able to add.

Apologies if it strays off topic a bit and what I have written appears to be complete twaddle Pip

GOOD Currency-Strength indie should include a factor for the specific currency share in the market.

Also, it should NOT include synthetic pairs in it’s calculation (reasoning explained somewhere else in this forum).

MA’s (if used) should be replaced by an adaptive means (Ehlers and others).

Indicator should include DYNAMIC Overbought/Oversold areas.

Trading decision should be taken based on several TF’s, preferably equaly spaced.

Trading decision based on CS should be supported by either momentum or volume indies.

Based on the above you can create a CS ROC, which will give you a better pair selection.

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Blog de Forex

Fundamental Indicators in Forex — Which to Use?

March 14, 2011 by Andriy Moraru

According to one of the polls, about 69% of traders employ fundamental analysis in Forex trading (at least minimally). I’ve already asked the readers of this blog what standard technical indicators they use. and now it’s time to ask the same about the fundamental indicators. Personally I believe that the fundamental factors play a huge role in how the currency pairs are traded. The fundamental indicators are deterministic for the long-term movement of the Forex rates. Unfortunately, it is very difficult to trade fundamentally in short-term. News trading is dangerous in and of itself, while the further direction of a position that was entered several hours after the expected fundamental release may still be rather unpredictable. Nevertheless, I prefer not to miss the opportunity to trade on such indicators as the global interest rates. GDP and unemployment data (especially, the nonfarm payrolls ). And how about you?

If you want to share your opinion or questions regarding the fundamental indicators worth using in Forex trading, feel free to reply using the form below.

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Freight Forward - June, 2017

Iron-ore inventory in China snapped its 4 month decline to recover marginally by 5% to 70.7 million tonnes however, it didn't support rates greatly. Capesize rates improved marginally by 5% MoM but rates are expected to weaken as supply supersedes demand. Panamax rates too decline amidst poor grain cargo from South America and lower cargo from Indonesia. Smaller vessels like Supramax and Hadysize demand remained flattish with rates declining marginally by 2% MoM. On capacity front, robust delivery to the tune of 5.3 million dwt in May 2017 however, neworder for May 2017 remained 2.6 million dwt also order book till CY 2017 in drybulk segment contracted to 97.1 million dwt against 101 million dwt in April 2017 providing marginal relief. Charter rates are expected to remain under pressure due to sluggish demand and no immediate revival.

RBI Action - Monetary Policy Update

Shipping Monthly Report - June 2017

The central bank kept the repo rate unchanged at 7.25%

CRR left unchanged at 4%

The marginal standing facility (MSF) rate left unchanged at 8.25%

Quick Comment - Mahindra & Mahindra

Mahindra & Mahindra (M&M) has entered into a multi-structured deal with Spain's CIE Automotive, which involves sale of stake in 3 entities of the Systech Automotive components division to CIE Automotives and then subsequent merger of the entities along with CIE Automotive's forging businesses in Spain and Lithuania into Mahindra Forgings, which will be renamed to Mahindra CIE. CIE Automotives will hold 51% stake in the entity and M&M will hold

20% stake. Furthermore, M&M will purchase 13.5% stake in CIE Automotives to become the 2nd largest shareholder.

Quick Comment - Gateway Distripark

Norwest Venture Partners (NVP) will invest | 60 crores in Gateway Distripark (GDL) subsidiary Snowman Logistics Limited (SLL) to acquire 14.3% stake in SLL valuing SLL at

|420 crores. Prior to the deal, SLL's Equity Capital was 10.29 crore shares with a face value of |10 each which is set to expand by 1.7 crores shares to 12 crores shares taking the equity base to |120 crores post deal. GDL, in order to keep its majority stake, bought 5% stake from one of SLL's shareholder (IFC) for a consideration of 18 crores (valuing each share at 35) prior to the deal. Post investment by NVP the shareholding pattern in SLL: GDL (51%), Mitsubishi (22%), IFC (13%) and NVP (14%). For details, click on the link below

Traditional Investments: Stocks and Bonds

As an investor, you have a variety of options to choose from, including stocks and bonds. The investment you select depends on your financial goals, your investment preferences, and your tolerance for risk.

These options represent traditional investments: You put your money down and hold on. Although you want to make changes as necessary to protect your investment, these types of investments can add stability to more aggressive — and riskier — investment strategies (like trading and hedging).

Investing in stocks

When you buy stock, you’re buying ownership in a corporation (or company). The benefit of owning stock in a corporation is that whenever the corporation profits, you profit as well. Typically, investors buy stocks and hold them for a long time, making decisions along the way about reallocating investment capital as financial needs change, selling underperformers, and so on.

As an investor, you want to make sure that your stock portfolio is carefully balanced among the different types of stocks (growth, value, domestic, international, and so on) and your other investments. A well-balanced traditional portfolio (which includes stocks and long-, short-, and intermediate-term bonds) generally offers a steady return of between 5 and 12 percent, depending on the specific investments and the amount of risk you’re willing to assume.

Investing in bonds

To raise money, governments, government agencies, municipalities, and corporations can sell bonds. When you buy a bond, you’re essentially lending money to this entity for the promise of repayment in addition to a specified annual return. In that sense, a bond is really nothing more than an IOU with a serial number. Some people, to sound impressive, call bonds debt securities or fixed-income securities .

Although some entities are more reliable than others, bonds generally offer stability and predictability well beyond that of most other investments. Because you are, in most cases, receiving a steady stream of income (the annual returns, for example), and because you expect to get your principal back in one piece (at the end of the bond’s life), bonds tend to be more conservative investments than stocks, commodities, or collectibles.

Definitive Agreement to Acquire Meotoiwa Paradise from Nagoya Railroad

NSSK is pleased to announce that today it entered into definitive agreements to acquire Meotoiwa Paradise Co, Ltd. ("Meotoiwa Paradise"; http://www. futami-seaparadise. com ) from Nagoya Railroad Co. Ltd.

Meotoiwa Paradise, is in Ise City, Mie Prefecture, and on a tour bus route from Ise Shrine. It is a shopping and entertainment arcade development that includes souvenir stores, restaurants and shops selling seafood and other local products. Contiguous with the arcade is Futami Sea Paradise, an aquarium which is famous for the close and personal encounter and interaction with walruses, seals and other marine mammals.

In close cooperation with local businesses, financial institutions and governments and in partnership with the employees, NSSK plans to help revitalize the business. The corporate carve-out investment in Meotoiwa Paradise illustrates NSSK's commitment to invest in local businesses with high growth potential in Japan's regional economy and represents its strategy of investing in businesses well positioned to benefit from increasing domestic and overseas tourist activity.

Yasuhiko Matsunaga Joins as Senior Advisor

NSSK announced today that Yasuhiko Matsunaga joined the organization as Senior Advisor. NSSK will benefit greatly from his extensive experience in finance.

Mr. Matsunaga started his career with the Industrial Bank of Japan, where he worked mainly on forex dealing and M&A advisory for 24 years. Since 1993, he had served as the Forex Chief Dealer for three years. Thereafter, he worked for IBJ Securities, Shinko Securities, and Mizuho Securities as Senior Executive. Since 2011, he had served as Head of Investment Banking and Head of Global Markets at Tokai Tokyo Securities. Currently he is the President of Tokai Tokyo Investment, a venture capital arm of Tokai Tokyo Financial Holdings.

Shinji Yamada Joins as Regional Operations Leader

NSSK announced today that Shinji Yamada joined the organization as Regional Operations Leader. NSSK will benefit greatly from his extensive experience in M&A advisory and management consultancy.

Mr. Yamada started his career with Mitsubishi Bank Ltd. where he worked in Japan and the US for 9 years and earned his MBA from the University of Chicago. Thereafter, he worked for Bain & Company as a management consultant, and then served as an M&A banker at Deutsche Securities, Mitsubishi UFJ Securities, Shinsei Bank and Tokai Tokyo Securities for 15 years. Currently, Mr. Yamada is the CEO of Intelligence Advisory Ltd. an independent advisory firm.

Izumi Ogura Joins as Senior Advisor

NSSK announced today that Izumi Ogura joined the organization as Senior Advisor. NSSK will benefit greatly from his extensive experience in both government and private financial sectors.

Mr. Ogura started his career with the Bank of Japan, where he worked mainly in the Money Market Operations Department and the Foreign Exchange Section of the International Department for 12 years. Thereafter, he worked for Dresdner Bank for about 10 years and then served as senior executive officers at Aozora Bank and Shinsei Bank for 11 years. During 2011-14, Mr. Ogura served as Head of Financial Service Industry for Abeam Consulting Ltd. and led approximately 300 consultants of the division.

Capital and Strategic Alliance with US. Mart Corporation

NSSK is pleased to announce its first investment in Mie-prefecture based US. Mart Corporation (Ise, CEO: Yoshihiro Taguchi, http://www. usmart. co. jp ). US. Mart is a leading owner and operator of indoor playground facilities (over 90 facilities throughout Japan) and franchisor of 100 Yen stores. NSSK and US. Mart entered into a definitive agreement on December 17, 2017 whereby NSSK will acquire a controlling interest (70%) in US. Mart and enter into a strategic alliance agreement with the company.

The company is looking to continue its expansion in Japan and will begin its international expansion into selected Asian markets. Given its rapid growth and future expansion plans, Mr. Taguchi has decided to engage with NSSK to help execute its strategic objectives by implementing NSSKвЂ™s NVP program throughout its operations.

NSSK will drive the companyвЂ™s growth by enhancing operations of existing stores as well as accelerating new store opening through NSSKвЂ™s business network.

Our Office is Open

We are pleased to announce the opening of the Nippon Sangyo Suishin Kiko Ltd. (NSSK) office at Atago Green Hills, Mori Building, 17th floor. We welcome all visitors to come hear the NSSK story.

Komli Media receives additional round of funding from NVP

Komli Media, Asia Pacific's leading digital media network, announced that it has raised US$ 15 mn in funding led by Norwest Venture Partners (NVP). Existing investors, Nexus Venture Partners and Helion Venture Partners, also participated in this round. The additional capital will be used to fuel aggressive expansion throughout India and across its key markets in Asia Pacific. The Company will further invest in its two core businesses – the Digital Media Network and the Audience Measurement unit - which are experiencing significant growth.

In 2010, Komli Media’s business grew over 600% while its employee base grew to 115, from 51 at the start of the year. Last year, Komli Media began its expansion across Asia Pacific by acquiring PostClick, Australia’s leading site representation firm. In October the Company further expanded to international ethnic markets with its acquisition of Indoor Media. With capabilities across brand solutions and performance marketing, Komli Media is Asia Pacific’s leading digital media network.

Amar Goel, Founder & Chief Executive Officer, Komli Media, said, “We were drawn to NVP because it is a global, top tier investment firm with deep domain knowledge in the online advertising sector. Furthermore, NVP’s powerful network of relationships in India and abroad will be of great value to Komli Media as we expand our offerings and services to other markets. We look forward to closely partnering with NVP to take our company to the next level.”

Komli Media's digital media network represents more than 2,000 websites today, including sites such as Facebook, Babycenter and Bloomberg, reaching more than 45 mn unique users across a number of categories and regions. The company also owns and operates ViziSense, India’s first and leading online audience and ad measurement platform. ViziSense is now being launched in Australia to tap the growing needs for cutting edge audience measurement from digital marketers and publishers.

Niren Shah, Managing Director, NVP India, joins Komli Media’s board of directors as part of today’s announcement. He commented, “NVP is excited about the potential of early and late stage Internet investments in India, and Komli is the perfect addition to our robust global Internet portfolio. Komli Media’s highly experienced management team, significant level of technical expertise, and strong operational and financial performance made our decision to invest in the company an easy one. We look forward to working with Komli Media and supporting the team as it innovates in unique ways that will cement its position as a market leader in the rapidly evolving Indian and Asia Pacific digital market.”

Prashant Mehta, Chief Operating Officer of Komli Media added, “As Komli Media expands its core operations in the fast growing Asia Pacific markets with a digital market size of more than USD 3 billion, we plan to leverage this funding to double our investment in our key products and platforms as well as scale our organization across sales and marketing.” He further added, “As we make these investments, we look forward to thought leadership and strategic guidance from the NVP team.”

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MP Abena Osei Asare Picks Nomination Forms

By Daniel Bampoe

MRS. ABENA Osei Asare, Member of Parliament (MP) for Atiwa East in the Eastern Region, has picked nomination forms, to contest the primaries for the second term as a parliamentary candidate of the New Patriotic Party (NPP) slated for June 13.

In 2010, she contested the party's primary as a result of the death of the incumbent MP for Atiwa and came in second with 36 per cent of the votes, losing to Mr Kwasi Amoako Atta who is now MP for Atiwa West.

When the Atiwa Constituency was divided into two following the passage of the Constitutional Instrument 78 which created 45 new constituencies throughout the country, she was elected as the party's parliamentary candidate.

Mr. Asare who won 16,449 votes out of the 23,361 valid votes cast=70.41% to defeated others such as Foster Asante (NDC) 6,480=27.74%, George Padmore Apraku (NVP) 237=1.01% and Boateng Okyere (PPP) 195=0.83% will be seeking the mandate of her constituents to represent them in Parliament.

Speaking to the DAILY GUIDE after picking the forms, at the constituency office over the weekend, she said she decided to contest again because she had an 'unfinished business 'in the Atiwa East Constituency.

She hinted that, though two strong men has also picks the forms to contest her but due to the numerous achievements she has done for her constituency in the past two years in office, she hopes the delegates will endorse her again to continue.

Explaining further, she said she had installed over 100 street lights across the length and breadth of the constituency and had plans to encourage the formation of neighborhood watchdog committees to per-empt crime in the constituency.

According to her, her outfits for the past two years in office has been able to distributes 400 pieces of solar lamps to her constituents, renovates of 3 classrooms blocks at Anyiman, facilitates 3 boreholes for Anyinam, renovates of public toilets, acquisition of loans for over 100 women to expand their business among other uncountable projects done for the constituency.

She averred that, her outfit has distriutes 40 latops and 20 desktops computers to both private and public School in her area and has recently lobbied for the Community Day SHS which will be very soon constructed at Anyinam.

Presenting the forms earlier to the MP, Adansi Pippim the Constituency Chairman, advise her to embark on a decent campaign, devoid of insults, lies and character assassination against her contenders, since they all belonged to the same family.

Profile Mrs Abena Osei-Asare, is one of the youngest MPs in the Sixth Parliament of the Fourth Republic who has work as a legislator to champion the hopes and aspirations of her constituents.

Since 2003, the Atiwa East legislator has nurtured the ambition to lead her people at the highest level of the country's political governance.

In December 2003, Mrs Osei-Asare was posted to the then office of the Presidential Special Initiative on Garment where she spent one year on national service.

She worked at the New York University (NYU) in Ghana between 2004 and 2007 as Assistant Director (Finance and Facilities), where she managed a budget close to $1 million annually and had added responsibility of all accounting and financial information for the university.

Poised to explore the world of employment, Mrs Osei-Asare sought employment at Barclays Bank Ghana Limited in 2007 and worked as Customer Team Leader between 2007 and 2009.

As a woman of the people, Mrs Osei-Asare has an NGO, Waterbrooke Foundation, which helps brilliant, and she has pay over 100 needy student's school fees.

The MP holds a Bachelor of Arts (Economics) degree from the University of Ghana. She also has a dealing certificate from ACI (Financial Markets Association) and is also a member of the ACCA.

She is a product of Wesley Girls High School-Cape-Coast (1995-1997), as she enjoys traveling, reading and listening to current affairs as well as volunteer work, especially with children.

The MP is married with two children.

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Nevirapine Once Daily

Reading Assignment Divisi Penyakit Tropik & Infeksi Departemen Ilmu Penyakit Dalam FK-USU/RSHAM Telah dibacakan PEMAKAIAN NEVIRAPINE SEKALI SEHARI Andi Raga Ginting, Divisi Penyakit Tropik Infeksi - Departemen Ilmu Penyakit Dalam FK USU - RSUP H. Adam Malik Medan PENDAHULUAN Penemuan obat antiretroviral (AV) pada tahun 1996 mendorong suatu revolusi dalam perawatan pasien HIV di negara maju. Meskipun belum mampu menyembuhkan penyakit dan menambah tantangan dalam efek samping serta resistensi kronis terhadab obat, namun secara dramatis terapi ARV menurunkan angka kematian dan kesakitan, meningkatkan kualitas hidup pasien dengan HIV, dan meningkatkan harapan masyarakat, sehingga pada saat ini HIV dan AIDS telah diterima sebagai penyakit yang dapat dikendalikan dan tidak lagi dianggap sebagai penyakit yang menakutkan.(1) Obat ARV terdiri dari beberapa golongan seperti nucleoside reverse transciptase inhibitor, nucleotide reverse transciptase inhibitor, non-nucleoside reverse transciptase inhibitor, dan inhibitor protease.(2) Baku pengobatan terdiri dari gabungan beberapa golongan obat, dan biasanya terdiri dari tiga obat atau disebut triple therapy dan kombinasi golongan obat HIV ini biasanya juga disebut dengan Highly Active Antiretrovial Therapy (HAART). WHO merekomendasikan bahwa rejimen lini pertama adalah 2 NRTI ditambah satu obat NNRTI.(3) NNRTI adalah golongan obat yang mengganggu proses penciptaan DNA virus dari RNA, dengan mengikat enzim reverse traskiptase dan menghalangi keiatannya. Bebepara penelitian menunjukan kepatuhan yang baik (>95%) terhadap rejimen antiretroviral dibutuhkan untuk mencapai supresi jangka panjang dari replikasi virus. Hal ini juga diketahui bahwa ketidakpatuhan menghasilkan resistensi virus terhadap obat dan kegagalan dalam pengobatan. Kepatuhan berbanding terbalik dengan jumlah dosis perhari. Dalam rangka upaya untuk menyederhanakan rejimen dan meningkatkan kepatuhan, maka dosis sekali sehari merupakan pilihan yang paling diinginkan oleh pasien yang terinfeksi HIV. Semakin banyak obat dari beberapa kelas dilisensikan untuk dosis sekali sehari (misalnya, tenefovir, evaп¬Ѓrenz dan atazanavir. Sebagai 1 tambahan, kelayakan dosis sekali sehari pada obat yang berlisensi untuk dosis dua kali sehari sedang di eksplorasi, salah satunya adalah nevirapine.(4) NEVIRAPINE Nevirapine (NVP) adalah suatu non-nucleoside reverse transciptase inhibitor (NNRTI) untuk HIV-1. Hal ini menghambat replikasi HIV-1 dengan mengikat langsung transkiptse-balik (reverse transciptase RT) dan memblokir sentrum katalisis enzim. Setelah NVP berikatan dengan RT, akan menyebabkan perubahan konformasi yang menginaktivasi enzim, sehingga mencegah polimerisasi RNA virus ke DNA. NVP sangat spesifik untuk RT HIV-1 dan tidak mengganggu polimerasi DNA manusia. NVP dengan bebas memasuki sel dan aktif dalam banyak sel yang berbeda, termasuk T-limfosit dan makrofag, target yang dikenal HIV; ini berbeda dengan analog n e u k l o s i d a ( N u c l e o s i d e re v e r s e transciptase inhibitor ), yang memiliki VOL. 37, 1993 PHA Plasma was assayed by hig after inactivatin aktivitas variabel dalam baris sel yang assay was valid from 25 to 10,00 berbeda. Tidak seperti NRTI, NVP tidak than 88% of th both nevirapine perlu terfosforilasi intrasel untuk menjadi free human pla interfering or c aktif; sebagai hasilnya, paparan obat curves were us coefficient of va mined from un sangat konsisten di dalam dan diantara different concen during the stud baris sel. NVP juga dapat mengikat RT deviations rang FIG. 1. Nevirapine, 5,11-dihydro-11-cyclopropyl-4-methyl-6H-dithe nominal val pyrido-[3,2-b2',3'e][1,4]diazepin-6-one (molecular weight, 266.302). virion ekstraseluler didalam plasma. Ini tion, defined as deviation of 8 asites) beresiko untuk menumpuknya NVP, dan yang lebih penting, NVP menimbulkan toksisitas hati. Dalam keadaan itu penggunaan NVP tidak dianjurkan. Jika NVP sangat diperlukan dalam kadaan seperti itu, pengurangan dosis harus dipertimbangkan.(5) Penelitian oleh Hong-Brown et al juga menunjukkan penurunan sintesis protein dalam miosit oleh karena keberadaan NVP dalam sel ini. Penurunan sintesa protein berkolerasi dengan penurunan tingkat fosforilasi dari translasi yang menginisiasi protein.(7) 4 Jenis Kelamin/Ras/Usia Tidak ada perbedaan yang cukup besar terhadap jenis kelamin atau ras yang dilaporkan dalam beberapa uji klinis. Di dalam satu penelitian fase I melibatkan sukarelawan yang sehat (15 wanita, 15 pria), berat badan-disesuaikan distribusi volume (Vdss) dari NVP lebih tinggi pada wanita (1.54L/kg) dibandingkan dengan pria (1.38L/kg), menunjukkan bahwa NVP di distribusikan lebih banyak pada wanita. Namun, perbedaan ini diimbangi dengan waktu paruh fase terminal lebih pendek pada wanita. Sehingga tidak ada perbedaan jenis kelamin yang signiп¬Ѓkan dalam konsentrasi NVP setelah pemberian baik dosis tunggal ataupun dosis ganda.(5, 8) Pada orang dewasa, farmakokinetik NVP tidak berubah jauh pada usia (berkisar18-68 tahun). Tingkat pembersihan yang nyata pada anak-anak mencapai maksimum pada umur 1-2 tahun, dan kemudian menurun pada waktu kewaktu. akibatnya dosis yang dianjurkan untuk anak 2 bulan sampai 8 tahun adalah 4mg/kg sekali sehari untuk 14 hari pertama setelah itu diikuti dengan 7 mg/kg dua kali sehari. dibandingkan dengan 4mg/kg sekali sehari untuk 14 hari pertama diikuti dengan 4mg/kg dua kali sehari pada anak-aanak usia 8 tahun dan lebih tua.(5) Studi Dosis Manusia Dosis harian 12.50, 50, 200, dan 400 mg diteliti pada pasien dewasa dengan hitungan CD4+ T-limfosit 250 cells/mm3 atau п¬Ѓgure 1, there is a clear demarcation in the risk dengan jumlah CD4+ Tpria of developing nevirapine-associated symptomatic hepatitis at the CD4 limfosit >400 cells/mm3 cell count cutoffs mentioned above. In our comprehensive (Gambar 3).(15)analyses, the freDiperlukan quency of patients with symptomatic hepatic events in the lowerlanjut untuk penelitian lebih CD4 cell count groups (women with counts !250 cells/ mengethui resiko mm3 and men withfaktor !400 cells/ counts 3 mm ) was signiп¬Ѓcantly reduced and was predisposisi pada pasien yang consistent with frequencies found in asGambar 3 Frequency of early symptomatic hepatic events in controlled and uncontrolled trials Figure 1. sociation with other antiretrovirals, inmengalami hepatitis, diduga with nevirapine. Data are from Boehringer IngelheimвЂ™s Expanded Hepatic Analysis and are included cluding efavirenz (1%вЂ“2%). We are conin EU/US VIRAMUNE prescribing information; вЂњearly symptomatic eventsвЂќ refers to events occurring pasien ko-infeksi during the п¬Ѓrst 6 weeks of treatment. cerned that, dengan study FTC-302 because for Long-Term Therapy !200 cells/mm3, the major predictive fac - Downloaded from http://jid. oxfordjournals. org/ by guest on April 8, 2012 hepatitis C mempunyai angka resiko lebih tinggi untuk mengalami hepatitis klinis ketika menggunakan terapi NVP.(16) CORRESPONDENCE вЂў JID 2005:192 (1 August) вЂў 545 PENYEDERHANAAN DOSIS Saat ini direkomendasikan bahwa NVP diberikan dua kali sehari; namun karena panjang paruh waktu pada kadar optimal (25-30 jam), dosis sekali sehari sering digunakan dalam praktek klinik. Label terbuka, acak, studi crossover oleh garcia van Heeswijk et al menunjukkan bahwa tidak ada perbedaan bermakna dalam keseluruhan paparan NVP (AUC) ketika dosis 400mg sekali sehari dibandingkan dengan 200mg dua kali sehari.(17) 7 patients with detectable HIV-1 RNA using NVP dosed to a 400 mg once-d to discontinue NVP because of HSR (2 ra Figure 1. Adverse events among patients initiating nevirapine Efп¬Ѓcacy Kadar terendah25 NVP ketika diberikan dosis sehari sekali adalah в€ј25% lebih patients (n=1,080), rendah jika Once daily Twice daily starting diberikan dosis dua kali sehari, ini masih jauh diatas IC50. Penelitian SCAN menemukan bahwaNVP hav 20 Patients, % 15 Antiretroviral efп¬Ѓcac (n=1,819), and trea P=0.001 NVP sehari sekali adalah efektif dan ditoleransi dengan baik sama seperti NVP dua kaliing detectable HIV-1 sehari pada 8.9 infeksi HIV tahap awal.(18) P=0.036 pula, penelitian Atlantic menunjukkan bahwa tiga preventing the Demikian P=0.041 load, obat 8.4 10 patients had a miss P=0.466 6.3 kombinasi termasuk dua nukleosida (didianosin dan stavudine) ditambah NVP dosis sekali sehari, NVP-ba 5 4.5 twice-daily 5 3.5 1.4 1.1 mempunyai efek antivirus dan CD+4 serupa dengan rejimen kombinasi termasuk duamen after a median nukleosida 0 ysis. A total of 734 NVP treatment and to a once-daily NV y h yang sama dan satu penghambat SR ty Hprotease (idinavir).(19) toxicit Ras xici y to NVP initiation. At to An pa Dari penelitian Calmy A et al. menyatakanHe inisiasi dosis NVP sekali sehari pada RNA was undetecta pasien yang median (IQR) CD4 Adverse event telah tersupresi replikasi HIV-1nya, dan juga pasien yang beralih dari dosis NVP dua kali sehari (311вЂ“670). At 96 weeks, 84% yang telah stabil ke rejimen sekali sehari, memiliki proп¬Ѓle yang baik (Tablel 2).(20) HSR, hypersensitivity reaction. a twice-daily regime compared with 86% Table 2. Multivariate logistic regression analysis of risk factors (P=0.540). KaplanвЂ“ Tabel 2. Multivariative logistic regression analysis of risk factors for hypersensitivity reactions. for hypersensitivity reactions ences between the gr able (log-rank P=0.7 Parameter OR (95% CI) P-value models conп¬Ѓrmed th Nevirapine dose/plasma viral load daily hazard ratio [H Twice daily/detectablea 1 вЂ“ In treatment-expe Twice daily/undetectableb 0.67 (0.47вЂ“0.94) 0.021 with detectable HIVOnce daily/detectablea 1.52 (1.00вЂ“2.30) 0.049 associated with a bet Once daily/undetectableb 0.44 (0.20вЂ“0.98) 0.044 as compared with p Low pre-HAART CD4+ T-cell countc 0.67 (0.48вЂ“0.93) 0.016 schedule (71% versu Low current CD4+ T-cell countd 0.65 (0.46вЂ“0.90) 0.010 table HIV-1 RNA f Asian ethnicity 2.89 (1.57вЂ“5.32) 0.0006 group, respectively; of the TLOVR show Model is stratiп¬Ѓed for cohort and adjusted for calendar year of starting nevirapine. aViral load was detectable at the start of nevirapine treatment. of virological failure b Viral load was below the lower limit of quantiп¬Ѓcation of the used assay at start with the once-daily c + of nevirapine treatment. CD4 T-cell count just before the start of combination antiretroviral therapy was 250 cells/mm3 for women and 400 cells/mm3 for 96 weeks of follow-u men. dCD4+ T-cell count at the start of nevirapine treatment was 250 cells/ However, the TLOV mm3 for women and 400 cells/mm3 for men. CI, conп¬Ѓdence interval; HAART, highly active antiretroviral therapy; OR, odds ratio. the adjusted Cox an 934 Negredo et al. meneliti keamanan dan kemanjuran pasien beralih dari berbagai rejimen dua AVT-09-OA-1262_Calmy. indd 934 kali sehari (dengan atau tanpa NVP) menjadi satu kali sehari nevirapin 400mg, dianosine 400mg dan tenofovir 300mg. (21) Total pasien 196, 85 dari mereka beralih ke rejimen sehari sekali. Setelah 48 minggu, 65 dari 85 pasien (76%) pada grup sehari sekali dipertahankan plasma viral load dibawah 50 copies/mL, dibandingkan dengan 72 dari 84% (86%) dalam grup yang masih melanjutkan dosis dua kali sehari (P=0.176). Efek samping yang menyebabkan pemberhentian pengobatan lebih banyak pada group sehari sekali. Tiga subjek (3.6%) yang melanjutkan dosis dua kali sehari diberhentikan terapinya dibandingkan dengan 12 subjek (14.1%) yang beralih ke dosis sehari sekali. Setelah 48 minggu. dalam grup dosis sehari sekali dilaporkan kepatuhan sebesar 97% dibandingkan dengan grup dua kali sehari sebesar 69.2%. Data ini menunjukkan bahwa manfaat dari peningkatan kepatuhan lebih dibandingkan dengan efek samping, dan dalam penelitian ini, kemungkinan berkurangnya efektiп¬Ѓtas virologi. 8 Ketika dibandingkan dengan dosis NVP dua kali sehari, rejimen antiretroviral dosis 400 mg sekali sehari yang diberikan setelah dua minggu pemberian awal 200 mg berhubungan dengan peningkatan resiko ruam yang menyebabkan penghentian pengobatan. Resiko komplikasi hati menjadi perhatian lainnya. Patoп¬Ѓsiologi dari meningkatnya angka efek samping tidak sepenuhnya diketahui. Walaupun penigkatan Cmax dengan NVP sehari sekali telah dipertimbangkan, sedikit bukti yang memperkuat hal ini dalam analisa farmakokinetik yang telah dipublikasikan. dan Formulasi extended-release NVP tersedia pada tahun 2011 untuk dosis sekali sehari. Data keamanannya awal percobaan klinis menunjukkan bahwa NVP bentuk extended-release memiliki khasiat antiviral sebanding dengan NVP biasa yang dosis dua kali sehari pada follow up 48 minggu. Penekanan virologi dicapai pada 80% pasien yang menggunakan formulasi realase dengan extendeddibandingkan 75% yang formulasi Gambar 4 menggunakan biasa(Gambar 4).(22) 9 DAFTAR PUSTAKA 1. 2. 3. 4. 5. 6. Pedoman Nasional Tatalaksana Klinis Infeksi HIV dan Terapi Antiretroviral Pada Orang Dewasa. Jakarta: Kementrian Kesehatan RI; 2011. Djoerban Z, Djauzi S. HIV/AIDS di Indonesia. In: Sudoyo AW, Setiohadi B, Alwi I, K MS, Setiati S, editors. Buku Ajar Ilmu Penyakit Dalam. 5 ed. Jakarta: Interna; 2010. p. 1825 - 9. Antiretroviral Therapy for HIV Infection in Adults and Adolescents. Austria: WHO; 2010. Cooper CL, van Heeswijk RP. Once-daily nevirapine dosing: a pharmacokinetics, efficacy and safety review. HIV Med. 2007 Jan;8(1):1-7. Harris M, Zala C, Hogg R, Montaner JSG. Nevirapine. In: Raphael Dolin M, Henry Masur M, Michael Saag M, editors. AIDS Therapy. 3ª ed. Philadelpia: Elseiver Inc; 2008. p. 233 - 45. Cheeseman SH, Hattox SE, McLaughlin MM, Koup RA, Andrews C, Bova CA, et al. Pharmacokinetics of nevirapine: initial single-rising-dose study in humans. Antimicrob Agents Chemother. 1993 Feb;37(2):178-82. Hong-Brown LQ, Brown CR, Lang CH. HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes. AIDS Res Hum Retroviruses. 2005 Oct;21(10):854-62. Cheeseman SH, Havlir D, McLaughlin MM, Greenough TC, Sullivan JL, Hall D, et al. Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):141-51. Havlir D, Cheeseman SH, McLaughlin M, Murphy R, Erice A, Spector SA, et al. High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. J Infect Dis. 1995 Mar;171(3):537-45. Pollard RB, Robinson P, Dransfield K. Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection. Clin Ther. 1998 Nov-Dec;20(6):1071-92. Wit FW. Experience with nevirapine in previously treated HIV-1-infected individuals. Antivir Ther. 2000 Dec;5(4):257-66. Wit FW WR, Horban A, Beniowski M, Schmidt RE, Gray G, Lazzarin A, Lafeuillade A, Paes D, Carlier H, van Weert L, de Vries C, van Leeuwen R, Lange JM. Prednisolone does not prevent hypersensitivity reactions in antiretroviral drug regimens containing abacavir with or without nevirapine. AIDS. 2001;15(18):2423-9. Barreiro P, Soriano V, Casas E, Estrada V, Tellez MJ, Hoetelmans R, et al. Prevention of nevirapine-associated exanthema using slow dose escalation and/or corticosteroids. AIDS. 2000 Sep 29;14(14):2153-7. Wit FW, Weverling GJ, Weel J, Jurriaans S, Lange JM. Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy. J Infect Dis. 2002 Jul 1;186(1):23-31. Leith J, Piliero P, Storfer S, Mayers D, Hinzmann R. Appropriate use of nevirapine for longterm therapy. J Infect Dis. 2005 Aug 1;192(3):545-6; author reply 6. Martinez E, Blanco JL, Arnaiz JA, Perez-Cuevas JB, Mocroft A, Cruceta A, et al. Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy. AIDS. 2001 Jul 6;15(10):1261-8. van Heeswijk RP, Veldkamp AI, Mulder JW, Meenhorst PL, Wit FW, Lange JM, et al. The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals. AIDS. 2000 May 26;14(8):F77-82. 10 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. Garcia F, Knobel H, Sambeat MA, Arrizabalaga J, Aranda M, Romeu J, et al. Comparison of twice-daily stavudine plus once - or twice-daily didanosine and nevirapine in early stages of HIV infection: the scan study. AIDS. 2000 Nov 10;14(16):2485-94. van Leeuwen R, Katlama C, Murphy RL, Squires K, Gatell J, Horban A, et al. A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1infected patients. AIDS. 2003 May 2;17(7):987-99. Calmy A, Vallier N, Nguyen A, Lange JM, Battegay M, de Wolf F, et al. Safety and efficacy of once-daily nevirapine dosing: a multicohort study. Antivir Ther. 2009;14(7):931-8. Negredo E, Molto J, Munoz-Moreno JA, Pedrol E, Ribera E, Viciana P, et al. Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach. Antivir Ther. 2004 Jun;9(3):335-42. Gathe J, Bogner J, Santiago S, Horban A, Nelson M, Cahn PE, et al. Comparison of 48 week efficacy and safety of 400 mg QD nevirapine extended release formulation (Viramune XR) versus 200 mg BID nevirapine immediate release formulation (Viramune IR) in combination with TruvadaВ® in antiretroviral (ARV) naГЇve HIV-1 infected patients (VERxVE). International AIDS Conference July 18 - 23; Vienna, Australia2010. 11

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Neurovive Pharmaceutical: Board Selects New CEO Erik Kinnman to Lead NeuroVive

NeuroVive Pharmaceutical AB (publ) board of directors is pleased to announce that it has selected Erik Kinnman as NeuroVive’s Chief Executive Officer (CEO). Erik Kinnman will assume the new role on the 14th March 2017, leaving Chief Medical Officer (CMO) and Chief Operating Officer (COO) roles within his own consultancy business.

“The NeuroVive Board and I are confident that Erik Kinnman is the right person to lead the company, its strategy, and leverage the opportunities. The combination of his strategic vision and medical expertise is an excellent fit with NeuroVive’s strategy refocused towards R&D. Erik Kinnman is a strong and experienced leader who has a proven ability to translate scientific, clinical and business strategy into execution," commented Gregory Batcheller, Chairman of the NeuroVive Board of Directors. "He will provide expertise and focus across the organization and establish solid partnerships that will enhance our R&D program further. His broad experience grounded in research, medicine and the biopharmaceutical industry is exactly what we need to lead this organization forward.”

“I am excited about NeuroVive, the CEO role, and the opportunity to contribute to the success and growth of the company. NeuroVive is a highly innovative organization and I am convinced that it has great potential in its range of novel treatment opportunities and their commercial potential. NeuroVive and its partners are truly led by a purpose and passion to make a difference and meaningful impact to patients affected by mitochondrial disorders. I will enable our researchers and partners to deliver on the opportunities in the clinical projects, as well as in the early pipeline to drive the value of NeuroVive.” says Erik Kinnman.

Erik Kinnman succeeds interim CEO Jan Nilsson, who will resume his position as Chief Operating Officer for NeuroVive. Jan has made significant contributions to move the organization forward. The recent partnership deals with both Isomerase and the University of Pennsylvania (UPENN) have been significant achievements under Jan’s leadership. Jan’s extensive NeuroVive knowledge and commitment to move the organization forward have been greatly appreciated by both the teams and board of NeuroVive.

NeuroVive Pharmaceutical AB (publ) is a pioneer in mitochondrial medicine and a company committed to the discovery and development of highly targeted candidates that preserve mitochondrial integrity and function in areas of significant therapeutic need. NeuroVive’s business approach is driven by value-adding partnerships with mitochondrial research institutions and commercial partners across the globe. NeuroVive’s portfolio consists of two clinical projects in acute kidney injury (AKI) and traumatic brain injury (TBI) with candidates in clinical and preclinical development and two drug discovery platforms. The NeuroSTAT® product has orphan drug status in Europe and in the US for treatment of moderate to severe traumatic brain injury and is currently being evaluated in a study, CHIC. Ciclosporin is being evaluated in an on-going study, CiPRICS, in acute kidney injury during major surgery. NeuroVive’s shares are listed on Nasdaq, Stockholm, Sweden.

NeuroVive Pharmaceutical AB (publ)

Medicon Village, SE-223 81 Lund, Sweden

Tel: +46 (0)46 275 62 20 (switchboard), Fax: +46 (0)46 888 83 48

NeuroVive Pharmaceutical AB (publ) - the mitochondrial medicine company. The company is listed on NASDAQ OMX Stockholm, Small Cap, under the ticker symbol NVP. The share is also traded on the OTC market in the US. NeuroVive Pharmaceutical (NEVPF ) trades on the OTC Pink Market. Investors can find Real-Time quotes and market information for the company at www. otcmarkets. com/stock/NEVPF/quote

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UPDATE -- Diclegis® (Doxylamine Succinate and Pyridoxine Hydrochloride) for Morning Sickness Preferred Through Indiana, Colorado and Nevada Medicaid Programs

Coverage for the Only FDA-Approved and Only Pregnancy Category A Prescription Treatment for Nausea and Vomiting of Pregnancy Expands to Indiana, Colorado and Nevada Through the State-Administered Medicaid Drug Rebate Programs

Press Release . Duchesnay USA – Tue 5 Jan, 2017 8:34 PM IST

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ROSEMONT, Pa. Jan. 05, 2017 (GLOBE NEWSWIRE) -- Duchesnay USA today announced that Diclegis® delayed-release tablets, for the treatment of Nausea and Vomiting of Pregnancy (NVP) in women who do not respond to conservative management, 1 are on the preferred drug list under the Indiana, Colorado and Nevada state-administered Medicaid programs.

NVP (commonly called morning sickness) is a very common medical condition, which is experienced by 70% to 85% of pregnant women. NVP can be quite debilitating throughout a woman’s pregnancy; however, treatment with Diclegis ® can help reduce NVP symptoms.

The addition of the Indiana, Colorado and Nevada Medicaid programs further expands availability to the already numerous commercially insured consumers that can currently access Diclegis ®. These three states join a growing list of influential State Medicaid programs, including California, Connecticut, Nebraska, Tennessee, Texas and Wisconsin, which cover Diclegis ® without special authorization requirements. Now, even more women across the country suffering from NVP will be able to receive Diclegis ® under state-administered Medicaid programs.

Diclegis ® is the only FDA-approved medicine for NVP and is safe and effective. 1 The FDA granted Diclegis ® Pregnancy Category A status 1. the best rating available. 2

For more information about Diclegis ®. visit www. Diclegis. com .

Diclegis is a prescription medicine used to treat nausea and vomiting of pregnancy in women who have not improved with change in diet or other non-medicine treatments.

Limitations of Use

Diclegis has not been studied in women with hyperemesis gravidarum.

Important Safety Information

Do not take Diclegis if you are allergic to doxylamine succinate, other ethanolamine derivative antihistamines, pyridoxine hydrochloride or any of the ingredients in Diclegis. You should also not take Diclegis in combination with medicines called monoamine oxidase inhibitors (MAOIs), as these medicines can intensify and prolong the adverse central nervous system (CNS) effects of Diclegis.

The most common side effect of Diclegis is drowsiness. Do not drive, operate heavy machinery, or other activities that need your full attention unless your healthcare provider says that you may do so.

Do not drink alcohol, or take other CNS depressants such as cough and cold medicines, certain pain medicines, and medicines that help you sleep while you take Diclegis. Severe drowsiness can happen or become worse causing falls or accidents.

Diclegis should be used with caution in women who have certain medical conditions, such as asthma (1), or eye (2, 3), stomach (4, 5, 6) or bladder problems. Tell your healthcare provider about all of your medical conditions so he/she can assess if Diclegis is right for you.

It is not known if Diclegis is safe and effective in children under 18 years of age. Keep Diclegis and all medicines out of the reach of children.

Diclegis is a delayed-release formulation, so signs of overdose may not appear right away. If you take too much Diclegis (overdose), you may have the following symptoms: restlessness, dry mouth, the pupils of your eyes become larger (dilated), sleepiness, dizziness, confusion, fast heart rate, seizures, muscle pain or weakness, and sudden and severe kidney problems. If you have these symptoms and they are severe, they may lead to death. Stop taking Diclegis, call your healthcare provider or go to the nearest hospital emergency room right away. For more information about overdose treatment, call your poison control center at 1-800-222-1222.

Diclegis is intended for use in pregnant women.

Tell your healthcare provider about all of your medical conditions, including if you are breastfeeding or plan to breastfeed. Diclegis can pass into your breast milk and may harm your baby. You should not breastfeed while using Diclegis.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www. fda. gov/medwatch or call 1-800-FDA-1088.

For additional important safety information, please see full Prescribing and Patient Information at www. diclegis. com. This information is not intended to replace discussions with your healthcare provider.

About Nausea and Vomiting of Pregnancy (NVP)

Nausea and vomiting of pregnancy (NVP), or morning sickness, affects 70 to 85 percent of pregnant women. 3,4,5,6 NVP can present differently for each woman, the symptoms include: nausea, gagging, retching, dry heaving, vomiting, and odor and/or food aversion. 7 For most pregnant women, symptoms generally cease at approximately 16 to 20 weeks. 6 However, some women can experience symptoms throughout their pregnancy. 8

Diclegis (doxylamine succinate 10 mg, pyridoxine hydrochloride 10 mg) delayed-release tablets are the only FDA-approved prescription treatment for nausea and vomiting of pregnancy (NVP) in women who do not respond to conservative management. 1 Diclegis has proven to be a safe and effective treatment option for NVP and received Pregnancy Category A status, which means the results of controlled studies have not shown an increased risk to an unborn baby. 1,2

About Duchesnay USA

Duchesnay USA is a unique healthcare company devoted to safeguarding the health and well - being of expectant mothers and their unborn babies. Its affiliate company, Duchesnay Inc. was founded in 1970 in Canada. The family-owned company realigned its business in 1992 to focus specifically on pregnant women after a family member experienced a very difficult pregnancy. Duchesnay’s mission is to develop pharmacological solutions to reduce the symptoms of nausea and vomiting during pregnancy (NVP). Duchesnay USA was established in Rosemont, Pennsylvania in 2011 to pursue that same mission. Realizing a lack of sufficient information on medications for use in pregnancy, Duchesnay strives today to ensure that expectant women who require pharmacological treatments have access to proper medical advice and therapies that are safe for them and their unborn babies. For more information on Duchesnay USA, please visit www. DuchesnayUSA. com.

1 Diclegis Prescribing Information. Duchesnay USA. 2017. 2 Department of Health and Human Services, Food and Drug Administration. Content and format of labeling for human prescription drug and biological products; requirements for pregnancy and lactation labeling. Federal Register. 2008; 73 (104):30831-68. 3 Jewell, D, Young, G. Interventions for Nausea and Vomiting in Early Pregnancy. The Cochrane Library. 2002; 1. 4 Medalie, J. Relationship between Nausea and Vomiting in Early Pregnancy and/or Abortion. The Lancet. 1957; 117-119. 5 Whitehead, SA, Andrews, LR, Chamberlain, VP. Characterisation of Nausea and Vomiting in Early Pregnancy: A Survey of 1000 Women. Journal of Obstetrics and Gynaecology. 1992; 12: 384-369. 6 Gadsby, R, Barnie-Adshead, A, Jagger, C. A Prospective Study of Nausea and Vomiting During Pregnancy. British Journal of General Practice . 1993; 43: 245-248. 7 Clark S, Costantine M, Hankins GDV. Review of NVP and HG and early pharmacotherapeutic Intervention. Obstetrics and Gynecology International Volume. 2012. 8 Jarnfelt-Samsioe, A, Samsio, G, Velinder, G. Nausea and Vomiting in Pregnancy – A Contribution to Its Epidemiology. Gynecologic and Obstetric Investigation. 1983; 16: 221-229.